GLP-1 medications are a class of prescription drugs that not only improves blood sugar control but may also lead to weight loss. This class of drugs is commonly called glucagon-like peptide 1 (GLP-1) agonists. Tirzepatide is a dual agonist, activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors. This combination can lead to even more significant weight loss than Semaglutide which just focuses on GLP-1. Weight loss can vary, depending on which GLP-1 drug you use and the dosage. Studies found people using GLP-1s and making lifestyle changes lost about 33.7 pounds (15.3 kilograms) versus 5.7 pounds (2.6 kilograms) in those who didn’t use the drug.